zyklische Peptide / Makrozyklen
Directed cys-cys disulfide cyclization
Cyclic peptides have drawn considerable interest because of their improved chemical stability and significantly enhanced resistance to in situ enzymatic clearance (oral peptides) . The conformation is more rigid then the open-chain analog and may explain in part some of the observed improved biological activities. We routinely prepare cyclic peptides with head to tail ring closure. Directed cys-cys disulfide cyclization is also frequently achieved, and careful monitoring of the reaction ensures 100% cyclization.
#Thioether; #Lactam; #Lactone
Thanatin Peptide
| Peptidname | L-AA-Sequenz; Gegenion: Acetat, >95% Reinheit, Menge: 5 mg | Price (without VAT, netto) **) |
| Thanatin Molecular Weight (MW) 2433.96 g/mol |
Sequence GSKKPVPIIYCNRRTGKCQRM (21mer) Modification disulfide bond: Cys11-Cys18 |
789,30 € |
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Cyclische Peptide
Peptide mit 1 oder 2 Disulfid-Brücken.
z.B.
synthetische Peptide mit einer Cys-Cys Disulfid-Bücke und einer Länge von 10-12 Aminosäuren [ L-AA] *)
Menge: 2 mg
Reinheit: >95%
Preis: ab 499,05 € **)
Genosphere Biotechnologies Peptidsyntheseservice.
eMail: info@genosphere-biotech.de
*) andere Längen sind ebenfalls erhältlich.
**) zzgl. Versandkosten pro Lieferung.
internal glutamic acid cyclization
N-terminal amine to internal glutamic acid cyclization of a 27 aa peptide containing 21 hydrophobic residue (theoretical molar mass 2894) was prepared (100 mg) with purity level >95% and a sample analyzed by MALDI-TOF MS. MS shows loss of H2O (-18 amu) by condensation to yield desired product with molecular ion at m/z 2895.0.
N-terminal cyclic peptide modification
[sata] = N-terminal S-acetyl-thioacetate
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