Cosmetic Peptides
Given the low bioavailability of relevant AMPs in nature, biotechnological interventions with genetic engineering and synthetic biology strategies for enhanced AMP synthesis have been a key focus in industry [1]. With this, as synthetic peptide development approaches have improved, the potential of synthetic AMPs to counteract pathogens and emerging infections has grown – they can now be designed with multifaceted mechanisms of action and act as antiviral, antibacterial and antifungal agents.
Key categories of AMPs currently in development include receptor-binding peptides, membrane-active peptides, membrane-lytic peptides and inhibitory peptides (such as cell wall-inhibiting peptides) [2]. AMPs generally affect highly preserved structures and can be used against specific targets such as peptidoglycans in Gram-negative and Gram-positive bacteria, and glucan in the fungal cell wall. Other peptides are particularly active on biofilm destabilizing the microbial communities. Synthetic peptides have also been marked as a potential solution to help combat antibiotic-resistant microbes such as drug-resistant Staphylococcus aureus. They can also act intracellularly – for instance, on protein biosynthesis or DNA replication [3].
As well as mimicking pharmacological properties, structural and amino acid sequence improvements can also be used to address challenges associated with natural AMPs, such as instability when used as a drug, host toxicity, rapid degradation by proteases and loss of activity in presence of serum and high salt concentrations [2,3]. Short-sequence AMPs (<20 amino acids) can be used to combine optimal antimicrobial activity with inexpensive chemical synthesis and modifications required to ensure stability, low toxicity and microbial specificity, and are compatible with large-scale production [4]. Mesh: #Antimicrobial #Peptides
Cosmetic Peptides
| Product | CAS Number | Purity (%) | Price (€) ; **) |
|---|---|---|---|
|
Pentapeptid-18 Synonym: Leuphasyl Sequence H-Tyr-[D-Ala]-Gly-Phe-Leu-OH |
CAS No. : 64963-01-54 Molecular formula: C29H39N5O7 Molecular weight: 569.6 |
cosmetic grade | Inquiry |
|
Hexapeptide-3/-8 Synonym: Argireline Sequence: Ac-EEMQRR-NH2 |
CAS No.: 616204-22-9 Molecular formula: C34H60N14O12S Molecular weight: 888.9 |
cosmetic grade | Inquiry |
|
Acetyl-Octapeptide-3 Synonym: SNAP-8 Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 |
CAS No.: 868844-74-0 Molecular Formula: C41H70N16O16S Molecular Weight: 1075.18 g/mol |
cosmetic grade | Inquiry |
| GHK-Cu (copper Peptide) Sequence: (Gly-His-Lys)2 Cu x HAc |
CAS No.: 89030-95-5 Molecular Formula: C14H24N6O4 Molecular Weight: 340.5 g/mol |
cosmetic grade | Inquiry |
|
Pal-GHK (Palmitoyl Tripeptide-1) Sequence: Pal-Gly-His-Lys-OH |
CAS No.: 147732-56-7 Molecular Formula: C30H54N6O5 Molecular Weight: 578.8 g/mol |
cosmetic grade | Inquiry |
| Myristoyl-Pentapeptide-17 Sequence: Myr-KLAKK-Amide |
CAS No.: 959610-30-1 Molecular Formula: C41H81N9O6 Molecular Weight: 796 g/mol |
cosmetic grade | Inquiry |
| Nonapeptid-1 Synonym: Melanostatine-5 acetate salt Sequence: H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 | CAS No.: 158563-45-2 Molecular Formula: C63H91N15O11S Acetat salt Molecular Weight: 1266.5 g/mol | cosmetic grade | 290 € / 200 mg |
| **) Preisangabe zzgl. gesetzliche MwSt. und zzgl 48 € Versandkosten pro Lieferung. | |||
| CONTINUE | Nur für die Forschung. Nicht für die Diagnostik. | Inquiry Form . Gerne erstellen wir Ihnen auch für andere Peptide und andere Mengen ein Angebot. |
Literatur
1. Sinha, R. & Dhukla, P. Antimicrobial Peptides: Recent Insights on Biotechnological Interventions and Future Perspectives. Protein & Peptide Letters 26, 79-87 (2019).
2. Chen, C. H. & Lu, T. Development and Challenges of Antimicrobial Peptides for Therapeutic Applications. Antibiotics 10.3390/antibiotics9010024 (2020).
3. Vanzolini, T. et al. Multitalented synthetic antimicrobial peptides and their antibacterial, antifungal and antiviral mechanisms. Int. J. Mol. Sci. 23, 545 (2022).
4. Rahnamaeian, M. & Vileinskas, A. Short antimicrobial peptides as cosmetic ingredients to deter dermatological pathogens. Appl. Microbiol. Biotechnol. 99, 8847–8855 (2015).
Oligopeptide-1
Topical application of sh-oligopeptide-1 with cosmetic preparations.
However, sh-EGF (sh-oligopeptide-1) is authorised as a cosmetic in several different concentrations for generalised use, with unknown long-term risks.
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